In this guide, SecondMuse offers a strategic framework for cities and states looking to take proactive steps in shaping inclusive, future-ready AI economies. Designed as a practical tool for city and state leaders, the guide moves beyond theory and outlines key levers for impactful change through policy, investment and workforce development, using ecosystem-driven practices to conduct strategic AI integration and build trust, resilience and competitive advantage. The playbook is validated across diverse industries and communities, building on real-world insights and SecondMuse’s decades of experience.